Everything You Wanted to Know about Indians from A to Z consists of twenty-six linen and rawhide medicine parfleches resting on a blue shelf. Each parfleche is identified with both a stencilled letter of the English alphabet and a corresponding Indigenous nation, beginning with the Aztec and ending with the Zuni.

By showing the alphabet as a piece of European technology and a microcosm of language, Houle questions the scientific strategies of ethnographic classification, critiquing how Indigenous sacred objects have been presented as curiosities.